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None of the treatment-emergent substitutions listed above in Mpro or Mpro cleavage sites occurred in PAXLOVID-treated subjects who experienced hospitalization

Final Action: After consideration of the public comments received, we are finalizing our proposal at new 180.90(c)(4) with clarifying edits, with an effective date of January 1, 2026

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translating to 4-5% reduction from baseline

Tip: Regular check-ins with your healthcare provider help fine-tune your dosage based on your body's response and progress

These findings indicate that liposomal encapsulation improves the bioavailability and bioactivity of gallic acid polyphenols (134)