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With respect to the previously mentioned study, this proof-of concept study has important methodological strengths residing in the availability of baseline and post-treatment hepatic biopsies

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As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease

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A key early sign of vitamin A deficiency are Bitots spots on the surface of the conjunctiva covering the cornea