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Moreover, the hepatic alanine aminotransferase (ALT) level was higher in KO mice, while the -glutamyltranspetidase (GGT) level was not changed (Supplementary Fig

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Mechanistically, this was associated with increased BrdU-positive neurons, preservation of dopaminergic neurons (via elevated tyrosine hydroxylase and dopamine transporter levels), enhanced antioxidant defenses (e.g., catalase, GPX1/2, HO-1), and upregulation of autophagy markers such as LC3-II and Beclin-1