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RSV administration has been associated with increased mRNA and protein expression levels of PGC-1 and SIRT1, promoting mitochondrial homeostasis, restoring respiratory capacity, and attenuating cellular injury (Zhang et al., 2020)

Ferroptosis also appears to have value in overcoming the resistance mechanisms of apoptosis-resistant tumours, for example in p53 mutated or Bcl-2 overexpressing cancers [253]

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Indeed metformin inhibits the mitochondrial oxidative phosphorylation complex I, leading to increased cellular AMP levels and subsequent stimulation of AMPK, an enzyme that plays key roles in the regulation of cellular energy homeostatis

Upendra Sharma , the founder and owner of the company

de Ferranti S, Mozaffarian D