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Additionally, the expression levels of insulin-secretion-related genes, including insulin receptor substrate 1 ( Irs1 ), glucose transporter member 2 ( Glut2 ), glucokinase ( Gck ), MAF bZIP transcription factor A ( MafA ), pancreatic and duodenal homeobox 1 ( Pdx1 ), insulin I ( Ins1 ), and insulin II ( Ins2 ), were significantly diminished in PA-treated NIT-1 cells, while Ex-4 treatment mitigated these alterations (Fig

CTNNB1/-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

Resveratrol, found in grapes and red wine, is known for its ability to neutralize free radicals and chelate metal ions

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Alternatively, it may cause the production of reactive aldehyde derivatives and hydroperoxyl radicals, which may cause secondary modifications to other cell components