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The magnitude of weight loss with semaglutide and tirzepatide places pharmacotherapy into a category that previously would have only been associated with surgical intervention

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[1] Commonly prescribed GLP-1 agonists include semaglutide (Ozempic for diabetes, Wegovy for weight management), dulaglutide (Trulicity), liraglutide (Victoza for diabetes, Saxenda for weight management), and exenatide (Byetta, Bydureon)

GLP-1s also reduce your appetite, so you end up eating less

Each tick mark on a 1 mL syringe represents 1 unit, which is 0.01 mL

This finding is consistent with a floor effect for hepatic fat, which is unlikely to be reduced below the median of 2.1% observed in the large UK Biobank study 27