294 , E142E147 (2008)
While we could not measure any changes in receptor conformational shift following exendin-4 binding between GLP-1R WT and V229A (Supplementary Figure 2B, C), quantification of GLP-1R plasma membrane diffusion coefficients using RICS in INS-1 832/3 SNAP/FLAG-hGLP-1R WT versus V229A cells revealed a pronounced reduction in GLP-1R V229A plasma membrane diffusion compared to WT GLP-1R under vehicle conditions (Figure 4A, B), to a similar extent to the reduction caused by exendin-4 binding to GLP-1R WT, as observed here and previously (33), and recapitulating the effect triggered by reduced cholesterol levels following simvastatin exposure (Supplementary Figure 1C, D)
47 ShangF.ZhangJ.LiZ.ZhangJ.YinY.WangY.et al (2016)
The impact of these medications on the microbiota (gut microorganisms) is less clear
GLP-1 receptor agonists work through multiple pathways
Your body naturally produces GLP-1 in your gut with receptor sites all over your body- brain, bone, blood vessels, heart, and many other places throughout your body
