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Clinical trials show both drugs yield significant weight loss and improved glucose control, but the response varies individually

Cardiovasc Diabetol 19:85 Breder I, Cunha Breder J, Bonilha I, Munhoz DB, Medorima STK, Oliveira DC, do Carmo HR, Moreira C, Kontush A, Zimetti F, Zanotti I, Carvalho LSF, Nadruz W, Muscelli E, Quinaglia T, Sposito AC (2020) EXCEED-BHS3 Trial Investigator

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In the pancreas, these medications enhance insulin secretion when blood glucose rises after meals while simultaneously suppressing glucagon release

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