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189 Until now there has been limited knowledge about the antioxidant status in AATD individuals, so the usefulness of antioxidant therapies remains to be investigated

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The antioxidant activity of the resveratrol is exerted by its capacity to neutralize free radicals but also from its ability inactivating the antioxidant enzymes such as SOD, CAT, and GPx (Izzo et al., 2021)

Glutathione and atherosclerosis Cardiovascular diseases are the leading causes of death in the US compared to any other cause (135)

The mRNA levels of multiple enzymes involved in the biosynthesis pathway using mitochondrial iron (heme and ironsulfur clusters) are downregulated

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