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Similarly, a study of Reddit users' self-reported side effects of retatrutide differed markedly from clinical trial data, including increased appetite, food cravings, and insomnia

On the brain side, the same peptide modulates serotonin, dopamine, GABA, nitric oxide, and glutamate systems

The main difference is losing the B12 component, so you may need separate B12 supplementation after switching

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It is important to discuss any concerns with your healthcare provider

Many patients benefit from monthly B12 injections or weekly oral supplements to maintain levels above 400 pg/mL