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Read more: Stopping a GLP-1: What to expect & how to manage weight after Do you have to taper off semaglutide

It is the sheer amount of weight lost in a short time

There is some evidence suggesting that certain SSRIs such as fluoxetine and sertraline may improve insulin sensitivity in some patients, though this effect is inconsistent and should not be relied upon for diabetes management

Abrupt discontinuation can lead to withdrawal symptoms or a sudden return of depressive symptoms

Aggregation: Improperly stored peptides may form insoluble aggregates, reducing effective concentration and bioactivity

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