Standardized difference (STD) was used to assess differences between the GLP-1 RAs and basal insulin group, with values of 50% eGFR decline, ESKD, or all-cause mortality, compared to either initiators of DPP4 inhibitors or sulfonylureas [28]
In other words, the claim is not that everyone will be harmed, but that a subset of patients who suffered severe and persistent symptoms may have experienced an abnormal or prolonged effect on digestion and intestinal movement
GLP-1 agonists are used to help manage type 2 diabetes and obesity as well as a few other conditions
Jstone Publishing
These concerns explain why doctors advise using approved medicines over untested alternatives with no proven results
In the coming years, patients and providers will have the options of newly launched biosimilars, novel GLP-1s, combination drugs, and approvals for allied indications