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Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have recently received Food and Drug Administration (FDA) approval for obesity management

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Even liraglutide stumbled because coverage was minimal

weight-loss curves keep descending, so longer trials report bigger numbers partly because they ran longer

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Of note, ex vivo isolated islet experiments do not simulate the full range of regulation present in vivo under T2DM conditions [207], which requires further investigation to clarify