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4 weeks 1 x 10 mL bottle 3 vials use 9 mL 6 weeks 2 x 10 mL bottles 6 vials use 18 mL 8 weeks 3 x 10 mL bottles 8 vials use 24 mL 12 weeks 4 x 10 mL bottles 13 vials use 39 mL Round up for priming losses, dropped syringes, and damaged swabs

Science 371 , 153159 (2021)

Acknowledgments: Gobierno de Extremadura-FEDER (GR15041)

doi: 10.3389/fmed.2022.904299 166 WangX.YangS.LiS.ZhaoL.HaoY.QinJ.et al

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In this type of constipation, discoordination of the musculature of the pelvic floor results in either inappropriate anal contraction, a failure of anal relaxation, or inefficient propulsion of stool