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While the mechanisms by which GLP-1R agonists exert their neuroprotective effects remain largely obscure (Reich and Hlscher 2022

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Cardiac NAD+ Restoration NNMT-mediated NAD+ depletion impairs mitochondrial function, sirtuin activity, redox balance, and energy metabolism in cardiac tissue

Conclusion The GLP-1 RAs in people with obesity or type 2 diabetes are associated with a significant reduction in all-cause death, alongside an increased risk of pancreatic adverse eventsparticularly acute pancreatitismost pronounced during the first 6 months of treatment

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