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Is in Stable Health: While the goal is to improve health, candidates should be in a condition that allows for treatments or medications without significant risks

Functional MRI trials consistently demonstrate reduced activation in mesolimbic and cortical reward circuits following treatment, reflecting diminished hedonic drive and a lower motivational response to high-calorie food cues (180, 181)

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Lean mass declines modestly (12kg average) but stabilizes by Week 8 post-cessation

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Many smartphones and wearable devices can measure these values at home