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1 (download XLSX Excel workbook with raw data Source Data Fig

Ethics statement All procedures were conducted in accordance with the regulations of the animal protection laws of China and approved by the Animal Ethics Committee of China Medical University (2012-38-1 and 2017008)

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3.1% with placebo) in people with obesity without diabetes, the highest reported among approved obesity pharmacotherapies [27]

Using an untargeted NMR-based approach, we identified and quantified 44 metabolites from a total of 52 detected (Figure S1, Table S1), excluding those with poor signal quality in the H-NMR spectrum or technical artefacts such as residual methanol