glp-1 npa The pharmacological basis for nonpeptide agonism of the receptor by orforglipron A science GLP-1 Supplement for Weight Management

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Compared with orally administered SGLT2 inhibitors, GLP-1RAs need to be subcutaneously injected, which appears to be a somewhat hurdle for patients to accept the therapy

This reduced response is driven by insulin resistance, diabetic medications (some of which promote weight gain), and metabolic dysfunction that blunts the full effect of GLP-1 therapy

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Clin Transl Sci 15(5):11671186 Pontes-da-Silva RM, de Souza MT, de Macedo Cardoso LE, Mandarim-de-Lacerda CA, Aguila MB (2022) Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist

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