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Individuals with CBS mutations will be slow to make glutathione.33 Flipping this around, individuals who have slow methylation cycle enzymes will have lower homocysteine levels

World Journal of Diabetes : Association Between Metformin and Vitamin B12 Deficiency in Patients With Type 2 Diabetes World Journal of Diabetes : Long-Term Metformin Therapy and Vitamin B12 Deficiency: An Association to Bear in Mind Diabetes, Obesity & Metabolism : Metformin-Induced Vitamin B12 Deficiency Can Cause or Worsen Distal Symmetrical, Autonomic and Cardiac Neuropathy in the Patient With Diabetes U.S

Take 2 capsules per day, 1 in the morning & 1 in the evening

J Biochem 103(6):907912

Additionally, it plays a key role in nerve function and the production of DNA and red blood cells

Just focus on the big things and then, once you get there, you can focus on optimization and experimentation with the little things