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Acute pancreatitis has been reported with GLP-1 agonists, and FDA labeling recommends discontinuing the medication if pancreatitis is suspected

By modifying the OXM peptide sequence with an amino acid-peptide substitution at position 2 to prevent DPP-4 action, in addition to a cholesterol-peptide conjugate, Pocai and colleagues were the first group to show that synthetic dual-agonists were an effective treatment strategy in an animal model