Statistical Analysis The experimental data acquired from cells and mice one-way ANOVA and shown as mean SD
It serves as a primary defender against oxidative stressan imbalance between free radicals and antioxidants that can lead to cellular damage
BeutlerEWestwoodBMelemedADal BorgoPMargolisD
Features DIM, milk thistle, and berberine
Further research needs to be deepened at multiple levels
1 Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age, with a global prevalence ranging from 11% to 13% based on the Rotterdam diagnostic criteria ( Growing evidence suggests that the gut microbiome plays a fundamental role in maintaining host metabolic, immune, and endocrine homeostasis ( Building upon these pathophysiological insights, recent clinical investigations have identified distinct gut microbial signatures in PCOS patients, characterized by reduced -diversity and specific taxonomic alterations that correlate with key clinical features ( 2 The gut-ovary axis The gut microbiota and ovaries engage in sophisticated bidirectional crosstalk through an integrated network of metabolic, immunologic, and neuroendocrine pathways
