Results from the TRIUMPH-4 trial, published in December 2025, showed participants with obesity and knee osteoarthritis taking retatrutide 12mg lost an average of 28.7% of their body weight at 68 weeks
The semaglutide food list and tirzepatide foods to avoid provide specific dietary guidance
While these are different mechanisms, combining dietary GLP-1 stimulation with pharmaceutical GLP-1 agonism warrants clinical oversight particularly regarding blood sugar and appetite effects
What happens if I miss a dose, do I lose steady state
Constipation: On the flip side, some individuals may experience constipation while taking GLP-1 medications, particularly if they have a history of gastrointestinal issues or a low-fiber diet
Why the Day Before Matters The day before your injection is when many people can eat a little more normally