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4 Limitations of Berberine Treatment Berberine has a variety of activities that may be involved in alleviating Alzheimers disease, including antioxidant, neuroprotective, and anti-inflammatory effects (Rabbani et al., 1987), it is generally considered to be non-genotoxic and cytotoxic in clinical (Liu et al., 2016

Mixed to negative

Applications include investigating cancer metastasis prevention, tumor suppression mechanisms, and oncogene regulation strategies

Coordinated changes of expression of key genes involved in other forms of regulated cell death such as pyroptosis, necroptosis, and apoptosis were notably absent (Figure S3CE)

The RAND American Life Panel: Technical Description