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Further studies on diverse ethnic samples are needed to confirm these findings and elucidate the genetic underpinnings of the T2DM-MDD relationship

Methods: We searched the Web of Science, Cochrane Central Register of Controlled Trials, PubMed, PsycINFO, and Scopus for relevant Randomized Clinical trials (RCTs) from inception until 1 August 2022

Walder RY, Walder JA

But the medicine is not suitable for everyone - it is important to speak with your doctor about whether it fits your health condition & treatment goals

For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. For now, the mechanism driving GLP-1 resistance remains unresolved, but it is likely complex and multifactorial, Gloyn said

This is why you should never assume the rules for a branded medication apply exactly to your compounded version