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The delayed release formula is intended to reach the lower intestines without succumbing to the harsh environment of the upper digestive system

Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously

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Find out if it worked, and learn if it helps with other conditions, in our updated answer to the question: What is Pycnogenol and does it work

The discrepancy is too large to be dismissed as a chance finding, suggest the researchers, but could be the result of publication biassome studies might have been prioritized for publication because of the positive nature of their results whereas the unpublished datasets used in this study would not have been affected by any failure to publish null results