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Acetyl-CoA, produced in the mitochondria via the action of the PDHc, will be transported out into the cytosol in the form of citrate when the energy charge of the cell rises

Monostori et al

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Its proven to ease symptoms of nerve damage and lower the risk of diabetic retinopathy (eye damage) that can occur with uncontrolled diabetes ( Its believed that this effect is due to the powerful antioxidant properties of alpha-lipoic acid ( Though alpha-lipoic acid has been shown to aid blood sugar control, its not considered a complete treatment for diabetes