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In this article, we review the promise of extended-interval GLP-1 therapies and the major challenges in achieving them, then examine the current state-of-the-art (including investigational agents advancing towards monthly dosing)
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Consider the delivery vehicle: Both are injectable, but peptides (MOTS-C) can sometimes be more sensitive to the pH of the reconstitution water than small molecules (1MQ)
Avoid contact with eyes.
You can also follow this general advice for managing side effects on GLP-1s: Eat smaller portions, more often, and more slowly Only eat when youre hungry, and stop when youre full Sip slowly on clear, cold drinks like water Avoid anything too sweet, spicy, fatty, or fried After eating, go for a gentle stroll in the fresh air The Possibility of a Temporary Weight Stall Tirzepatide is generally considered more effective, so when you switch from tirzepatide to semaglutide, you may experience an increase in your appetite and some rebound weight gain