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Food Technol Biotechnol

For sterile products, FDA expects manufacturers to demonstratenot assumethat contamination risks are effectively controlled

A shift in carbon flux from -oxidation to the riboflavin biosynthetic pathway was proved by a twofold increase in ADE1 , RIB1 , and RIB5 protein synthesis, and in gene expression of gluconeogenesis and pentose phosphate cycles, but it was observed that the downregulation of pathways were related to carbon source assimilation, energy generation, and glycolysis at the riboflavin-producing phase (Table 3

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The development of highly selective and structurally optimized CYP51A1 inhibitorsor context-specific modulatorscould provide valuable therapeutic strategies, particularly in hormone-sensitive cancers, immune regulation, and metabolic diseases

Jing, L., Wu, N., Zhang, J., Da, Q