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News-Medical+3EurekAlert!+3ASMBS+3 To put numbers on it: Surgical patients lost ~58 lbs in two years ( 24% of total body weight, or TBW) GLP-1 patients lost only ~12 lbs ( 4.7% TBW) over the same period EurekAlert!+2News-Medical+2 Even among GLP-1 users who continued therapy for a full year, weight loss averaged only ~7% TBWstill far less than surgical outcomes EurekAlert!+2ASMBS+2 Another rigorous analysis published in JAMA Surgery compared weight loss surgery and GLP-1 receptor agonists over two years

They stimulate insulin secretion in pancreatic -cells, but their effects on glucagon production in pancreatic -cells differ: GIP has a glucagonotropic effect during hypoglycemia, and GLP-1 exhibits a glucagonostatic effect during hyperglycemia

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Although many other GLP1R agonists and GLP1R/GR dual agonists are in development, preliminary findings suggest that activation of GIPR is required to produce favourable side-effect profiles