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Unveiling the potential role of glucagon-like peptide-1 (GLP-1) receptor agonists in offering protection of the cardiovascular, renal, and neural systems: an updated narrative review

Side effect comparison The side effect comparison between semaglutide and tirzepatide shows that GI side effects are a class effect of GLP-1 agonism

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Nausea hits 36.9% of GLP-1 users per Nature Healths 2026 analysis of 67,008 self-reporters

Indeed, early retrospective cohort studies and post-hoc analyses suggested that GLP-1RAs might delay DR progression or improve outcomes, with one study reporting that 80% of patients on continuous therapy achieved either improvement or stabilization of their DR status [78, 79]

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