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27 Pharmacological intervention can significantly reduce pain intensity and flare duration, e.g

Notably, mitochondrial dysfunction, a hallmark of senescent chondrocytes in OA, induces intracellular ROS production that causes oxidative stress

The levels of Bcl-XL decrease with mitochondrial clearance during reticulocyte maturation together with its deamidation [115]

3.2 Combination Therapy The heterogeneity of cancer metabolism, even within the same tumor [62], poses many challenges for potential drug therapies