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Those with specific medical needs might benefit from weekly treatments under medical supervision

It is reported that 5-ASA ameliorates UC in mice through dual mechanisms of preserving intestinal epithelial barrier integrity and modulating gut microbiota composition, with concomitant suprpression of JNK and p38 MAPK phosphorylation in colonic macrophages (Qu et al., 2017

PMID: 35083444

mechanisms discussed in the article include copper binding, extracellular matrix signaling, fibroblast activity, collagen-related pathways, matrix metalloproteinase regulation, glycosaminoglycan synthesis, and inflammation-related pathways

Higher water volumes reduce concentration but require a larger draw

9. May reduce the impact of uncontrolled diabetes 10. May reduce respiratory disease symptoms