Neurology 104 (6), e213447
Patients taking GLP-1 agonists most commonly complain of gastrointestinal effects, 2 such as unsettled stomach, upset GI tract, variable bowel movements or trouble with elimination, abdominal discomfort, and gastroesophageal discomfort
Orforglipron is in Phase 3 clinical trials now
At present, the studies of EX on non-diabetic obesity mainly include 152 cases of simple obesity (weight loss of 5.1 kg) (54), 60 cases of polycystic ovary syndrome (weight loss of 3.2-6.0 kg) (55), and 10 cases of metabolic syndrome (weight loss of 3.7 kg) (56), among which the most common adverse reaction is still vomiting
A focus on nutrition is largely missing from the healthcare system
8,9,10 These mechanisms make GLP-1RAs powerful tools for controlling blood glucose and improving metabolic syndrome