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Sporadic ALS astrocytes induce neuronal degeneration in vivo

Antioxid Redox Signal 28(18):17241745 Kumari M et al (2021) Tocotrienols ameliorate neurodegeneration and motor deficits in the 6-OHDA-induced rat model of parkinsonism: behavioural and immunohistochemistry analysis

Because exosomes and many peptides are pro-growth, they can be risky in active cancer or where malignancy is suspected

AOD-9604, as a C-terminal fragment lacking affinity for the growth hormone receptor, avoids these metabolic complications

Hubert HB, Feinleib M, McNamara PM, Castelli WP

We also know that certain populations pregnant or breastfeeding women and people with a history of cancer are contraindicated for peptide use