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Neurotransmitter Synthesis: Neurotransmitters, chemicals vital for brain function and mental health, rely on PLP for their synthesis

The model contains only 13 zonation-dependent kinetic parameters (Supplementary Material), and metabolic zonation was simulated by manually changing enzyme activities depending on the zone that the cell belongs to, either the periportal or pericentral region

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(2) ENS neurological repair via Lion's Mane (NGF stimulation) and ALCAR (neuronal energy and acetylcholine)

Abbas et al., 2023a) and exhaustion of antioxidant defenses, like downregulation of GSH and the Nrf2/heme oxygenase-1 signaling (Bu et al., 2018)

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