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Not because the medication impairs cardiovascular function, but because reduced caloric intake lowered muscle glycogen storage capacity below the threshold needed to sustain marathon pace beyond 90 minutes

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Heart rate considerations: According to the Mounjaro SmPC, tirzepatide can cause a modest increase in heart rate (typically 24 beats per minute on average), while beta blockers reduce heart rate

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Quality of life improvements and clinical assessments in kidney transplant recipients undergoing pegloticase treatment for uncontrolled gout: findings of the phase 4 PROTECT clinical trial