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PubMed Mathiesen, D.S., Lund, A., Vilsbll, T., Knop, F.K., & Bagger, J.I

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When NRX is oxidized by NADPH oxidase 1 (NOX1)-derived H2O2 or lipid peroxide (ROOH), DVL is released and inhibits glycogen synthesis kinase 3 (GSK3) in the -catenin degradation complex, thereby stabilizing the -catenin in the cytoplasm and partially entering the nucleus to activate the target gene GPX2 by correlation with the TCF/LEF transcription factor family (Figure 2)

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Many researchers use all three together for multi-target hair restoration