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According to a study by Fang et al, increased plasma PAGln levels and improved microbiota-derived PAGln synthesis-related functions were linked to in-stent stenosis and hyperplasia in CAD patients

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[DOI] [PubMed] [Google Scholar] 72.Chen W.R., Hu S.Y., Chen Y.D., Zhang Y., Qian G., Wang J., Yang J.J., Wang Z.F., Tian F., Ning Q.X

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Some improvements in insulin sensitivity and inflammatory markers can begin emerging within 4 to 8 weeks of treatment Leptin normalization, however, follows actual fat mass reduction rather than drug exposure directly, meaning those benefits likely take months of sustained treatment

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