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More comprehensive insight into the effects of GLP-1 RAs on gastrointestinal and central nervous system functions is required

Although there are some experimental skin patches where GLP-1 agonist medicines like semaglutide are used as active ingredients, these are still under trial and not yet approved for use

The New England Journal of Medicine, 387 (3), 205216

What do these trial results mean in practical terms

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Common side effects include: Nausea and vomiting Digestive issues like diarrhoea, constipation, or abdominal pain Headaches and fatigue Injection site reactions Serious but less common side effects: Pancreatitis Gallbladder problems Kidney problems Low blood sugar Most gastrointestinal side effects settle within the first month or two