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1985 Jun;239(2):538-48. [PMID: 4004275]

Often associated with poor outcomes, acute crises were not observed for a five-year follow-up period following thiamin supplementation (300-400 mg/day) early diagnosis and immediate treatment with biotin and thiamin led to positive outcomes (118)

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Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

Without these trials, the practical application of these strategies remains limited, and their long-term effects on healthspan and lifespan are uncertain (Longo et al., 2021)

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