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Samples were digested with aqua regia and Cu 2+ content was determined by ICP-MS (Agilent 7700, Germany)

Synthesis of Amodiaquine Quinoneimine (AQ-QI) and Desethylamodiaquine Quinoneimine (DEAQ-QI) Synthesis of AQ-QI and DEAQ-QI was adapted from a method published previously, with a few modifications ( in vacuo and then applied to a silica-60 column to remove the tracing AQ or DEAQ

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Because the prevalence of CVD in the population with T2DM is around 32% [33], at least one fourth of the average patient with T2DM is possible a candidate for the use of the GLP-1RA, or sodium-glucose transporter-2 inhibitors [34], to improve the MACE outcome

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Regulatory Status: Retatrutide is an investigational drug, still in Phase 3 clinical trials, and not yet approved by regulatory bodies like the FDA