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Such heterogeneity is consistent with the large total levels of heterogeneity (I = 99.21%), indicating large differences among studies in terms of design, population of the study, types of GLP-1 RAs, or duration of treatment

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Unlike older weight loss medications, tirzepatide activates two separate metabolic pathways, which research shows can produce more substantial and sustained weight reductions

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When used for weight management, the evidence increasingly supports long-term or indefinite treatment for patients who respond well and tolerate the medication particularly those with obesity-related cardiovascular risk factors