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The following mechanisms are responsible for high vitamin B12 blood values in such diseases: Overproduction of haptocorrin Mistaken excretion of vitamin B12 Release of large quantities of B12 from the bodys store in the liver Production of B12 analogues through bacterial overgrowth Below is a list of the most common diseases associated with very high vitamin B12 blood levels

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Each bulk vial closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents

Unlike deficiency states, which produce well-characterised neurological and haematological symptoms, there is no clearly defined clinical syndrome associated with B12 excess from supplementation alone