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This can lead to confounding by indication, or channelling bias, meaning that the exposure to the drugs being tested are influenced by patients characteristics or comorbidities and such characteristics then drive differential outcome more than the drugs themselves

However, many peptides currently being discussed in wellness and longevity medicine are not FDA-approved for the uses commonly promoted in those settings

For some individuals, their medical conditions or specific nutritional needs necessitate vitamin B12 injections to ensure they maintain adequate levels in their body

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The injection is once per week, and does not have the timing or empty-stomach requirements that the pill does