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However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC

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C., Gambaro, G

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Metabolic States and Conditions Requiring Caution Patients with G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency) face increased risk of hemolytic anemia when taking glutathione supplements

C.PedersenL.BorghammerP.et al (2015)