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[5] Administering 100,000 IU intramuscularly establishes a high-capacity depot that may correct deficiency more predictably than oral dosing in malabsorption syndromes and maintains adequate circulating vitamin D over two to three months, an approach often referred to as Stoss therapy in endocrinology

This elevated cyclic AMP activates protein kinase A (PKA) and Epac2 pathways to potentiate glucose-dependent insulin secretion and insulin exocytosis, respectively [6]

Focus on FP: Clostridium mixtures ( FP , Bacteroides faecis, Roseburia intestinalis) restore the Treg/Th17 balance in DSS-induced UC mice, increase IL-10 and IL-4 secretion, reduce pro-inflammatory factors such as TNF, IL-1, and IL-17, and repair the intestinal barrier (104)

According to the authors, PepGen appeared to offer a safe, economical and clinically useful alternative to autologous grafting

Never mix them in the same syringe