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Tandon R, Thacker J, Pandya U, Patel M, Tandon K

If you are considering starting B12 supplements, particularly at high doses, discuss this with your GP or a registered pharmacist, especially if you have existing medical conditions or take other medications

Pernicious anemia is an autoimmune disease characterized by the absence of intrinsic factor, a glycoprotein that is necessary for vitamin B 12 absorption [25, 26]

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20mg vial U-100 syringe marks 12.5 u=2.5 mg 25 u=5 mg 37.5 u=7.5 mg 50 u=10 mg 1 ml keeps draws smaller: 2.5 mg is 12.5 units (halfway between 12 and 13 on most U-100 syringes)

The presence of funnel plot asymmetry also suggests potential publication bias, which warrants further scrutiny