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Nitric oxide levels significantly increased in the PFC but not in the CC of mice that received 12 weeks of a 0.2% cuprizone-enriched diet

In human T cells, ChAT mRNA expression is induced via the activation of the PI3K signaling cascade (124)

In response to stress, hepatocytes release pro-inflammatory mediators and damage-associated molecular patterns (DAMPs), leading to the activation and infiltration of immune cells, which further exacerbates hepatocyte damage

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ChemRxiv , 2021, 17