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Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified

A continuous exposure might be necessary for chronic studies, whereas acute investigations might only require a single dose

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Thus, significant efforts are presently directed at designing drugs capable of slowing the progression of disease symptoms, with the ultimate goal of halting and reversing the underlying causes of AD

170 Eleven patients in the lidocaine group (68.7%) responded to treatment