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That gap can mean the difference between effective and ineffective treatment

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*Correspondence: Thamir M

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Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution

A multidisciplinary expert consensus published in 2022 suggested pausing or reducing the dose of metformin therapy during initiation of a GLP-1 RA as an option to reduce GI side effects (Gorgojo-Martnez et al, 2022), although this is not widely practised in the UK